Effects of a Chinese medicinal plant Radix astragali on the ovariectomized female rats
The aqueous extract of Astragalus membranaceus can significantly improve the cognitive function of hypoxic rats, with potential mechanisms related to the alleviation of oxidative stress, reduction of free radicals and metabolite accumulation, and activation of the mechanistic target of rapamycin (mTOR) signaling pathway ( in vivo experiment using cerebral ischemia/reperfusion (I/R) injury as a model reported that AS-IV isolated from Astragalus membranaceus can prevent brain edema and BBB breakdown, through the upregulation of matrix metalloproteinase-9 (MMP-9) and aquaporin 4 (AQP4), mediated via the activation of the Nrf2 signaling pathway ( Astragalus membranaceus on brain injuries associated with high-altitude hypoxia, and suggest its potential value as a neuroprotective agent
In the literature it often appears under the name Body Protection Compound 157 or bepecin
[DOI] [PubMed] [Google Scholar] 243.Wang H., Poe A., Pak L., Nandakumar K., Jandu S., Steppan J., Lser R., Santhanam L
Tom Biernacki, DPM is a double board-certified podiatrist and foot & ankle surgeon at Balance Foot & Ankle Specialists in Southeast Michigan
Research has also suggested that exercise can reduce oxidative stress by increasing glutathione levels
